From previous trials, the association between ciprofloxacin and acute renal failure, probably realized through immunological-like mechanisms, was signalled. An Italian trial now presents two cases of possible induction of crystal-induced nephropathy by ciprofloxacin. In both cases, (older) patients’ creatinine was about 1.0 mg/dl. Treatment consisted in the administration of 750 mg ciprofloxacin twice a day: after this intake, in a patient creatinine increased up to 7.0 mg/dl and in the other up to 8.3 mg/dl, with a renal biopsy which revealed in both cases the presence of star-like crystals in some tubules. Crystals, with a negative reaction for calcium and phosphates, were identical to the ciprofloxacin crystals described in previous trials.
(Nephrology)
Our comment:
February 2008
-
Fast speaking - File size: 1382 Kb Time 1,28 min.
-
Slow speaking - File size: 1525 Kb Time 1,37 min.
We know there is a relation between high levels of homocysteine and cardiovascular diseases, even [...]
The pediatric syndrome characterized by attention deficit and hyperactivity (ADHD) has been [...]
When we are in front of patients with “chronic” perineal pelvic pain, we often speak of chronic [...]
Decisive results on the usefulness of calcium in the prevention of fractures still lack, so, a [...]