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When a hyperlipemia is present, we can often find high levels of transaminases as an effect of non-alcoholic fatty liver disease (NAFLD), and previous trials have suggested that statins can decrease the levels of transaminases, improving liver histology. In these patients, however, there is an [...]
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Guidelines recommend the use of a beta-blocker or an endoscopic ligation in order to prevent the risk of the first bleeding due to the rupture of esophageal varices in liver cirrhosis, while, for the prevention of relapses, the association of ligation with beta-blocker has been more effective than [...]
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We have not got a specific therapy for non-alcoholic steatohepatitis (NASH), since there are many trials on various substances, but most of them are not randomized or they have been too short or with endpoints of unclear efficacy. Now, a phase-III, multicentric, double-blinded trial has been [...]
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From previous trials, we know that the presence of overweight can imply even severe risks for the liver, but the interaction between overweight and alcohol intake is not completely cleared up yet, so some answers to this situation are searched. In a retrospective trial performed in Scotland, 9600 [...]
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Some patients affected by non-alcoholic steatohepatitis (NASH) present other clinical conditions (hyperlipidemia, diabetes) for which a moderate alcohol intake implies some benefits, but we know which are the effects of a moderate intake of small amounts of alcohol on NASH, a clinical entity with [...]
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It is normal to see very variable limits in the normality range as to the values of transaminases, according to the laboratory performing the exam, and this variability often creates some problems to the patient and to the general practitioner, since an increase in this parameter could mean a liver [...]
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Since the use of statins is associated with a reduction in cholesterol production, these drugs should theoretically have a role in cholesterinic biliary lithiasis, but the trials performed up to now have only given inconclusive results. Now, some researchers in England have used a registry of [...]
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Paracetamol-induced liver toxicity (both following an ingestion of high doses and for very-long-term therapies) is the commonest cause of acute liver failure in the USA, so researchers have wondered on the problem of the safety of analgesics and OTC NSAIDs. In order to better evaluate their [...]
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Non-alcoholic fatty liver is more and more increasing and not only as a histological curiosity, but also as a clinical condition implying even serious consequences. Thiazolidinediones, approved by FDA for diabetes treatment, improve liver histology in diabetic patients, so researchers have thought [...]
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In patients affected by chronic hepatitis B, one generally decides the execution of a liver biopsy and a possible treatment according to liver enzyme levels. But there are some uncertainties on the progression of the disease in patients presenting normal levels of liver enzymes. A trial was [...]