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The management of reflux disease – when it becomes severe – is controversial, because a part of physicians are inclined to surgery and another one to medical therapy. In order to make a direct comparison between a PPI and anti-reflux endoscopic surgery (LARS: laparoscopic antireflux surgery) some [...]
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The association between chronic pancreatitis and alcohol intake is given for granted, but recently, new associations have been discovered that can partly change the etiology of this disease. The data from 539 patients and 695 controls (patients’ first-line relatives, partners and friends) [...]
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A study in 2010 – called COGENT – has shown that omeprazole prevents the negative gastrointestinal reactions in patients taking aspirin and clopidogrel, without increasing cardiovascular risk. In the study sample, however, only 4% of them had a positive history for peptic ulcer or gastrointestinal [...]
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In patients affected by irritable bowel syndrome, some alterations of gut flora can be found, so, in the treatment of this frequent condition, the use of antibiotics with an intestinal action has been proposed. Through the sponsorship of a pharmaceutical company, some researchers have randomized [...]
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When a patient undergoes hemorrhages or intestinal bleedings coming from terminal bowel, is it opportune to perform an urgent colonoscopy? Some researchers in California have enrolled 85 patients (averagely 52 years of age; average Hb 7.9 g/l) affected by hemodinamically significant hematochezia [...]
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With a double-blinded, placebo-controlled study, some Italian researchers have randomized 44 infants older than 6 months of age (averagely 8 months of age) with chronic functional constipation to receive a probiotic suspension (Lactobacillus Reuteri) or placebo, administered once a day 30 minutes [...]
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Observational trials have suggested that protonic pump inhibitors (PPIs) reduce the efficacy of antiplatelet agents, so a patient under treatment with clopidogrel should use other forms of gastric prevention. In order to verify if things are really this way, the researchers of the COGENT trial have [...]
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In a randomized trial performed in 2009, some asymptomatic volunteers have developed dyspeptic symptoms after being treated for 8 weeks with esomeprazole. Now, some Swedish researchers have examined the rebound phenomenon after the interruption of a therapy based on protonic pump inhibitors. 48 [...]
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In some cases, there is the problem to administer NSAIDs to patients with a high risk of intestinal bleeding, so a comparative trial has been performed to try to establish which are the molecules to be avoided in these situations. A meta-analysis has been performed on 9 studies (2 cohort studies [...]
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The presence of inflammatory bowel diseases (IBD) is an increased risk for venous thromboses; in fact, patients hospitalized for this disease are often put under preventive therapy with anti-thrombotics. In order to quantify this risk, some English researchers have used their database to identify [...]