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Previous studies were unable to demonstrate the effectiveness of statins in the prevention of cardiovascular events in patients on dialysis. A group of investigators carried out SHARP, a randomised trial funded by the pharmaceutical industry, in which the combination of simvastatin plus ezetimibe [...]
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The presence of albuminuria can be ascribed, in many cases, to a vascular damage, concerning microcirculation, with a mechanism presenting points of contact with cognitive decline due to cerebral-vascular deficiency. Beside the common pathogenetic mechanism, are there tighter relations between [...]
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An acute renal failure obviously increases the risk that an already existing chronic failure evolves towards a terminal stage and consequently increases specific mortality. Acute renal failure (often caused by drugs or means of contrast) could in many cases be prevented, since a low value of [...]
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In patients affected by chronic nephropathy, a pressure target of 130/80 mmHg is advised (American Journal of Kidney Diseases 2003; 42 (Suppl 3):S1), but a support for strong evidence on this recommendation lacks. With a retrospective cohort study, 8,000 elderly have been identified (≥ 75 years of [...]
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Chronic renal failure is associated with an increased risk of coronary artery diseases, cardiovascular mortality and mortality for any cause, but the link between the value of glomerular filtration and stroke has not been completely cleared up yet. For this reason, this meta-analysis has been [...]
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We know that an advanced-stage chronic renal failure is associated with an increase in cardiovascular mortality, so, with this prospective trial performed in Iceland and concerning 17,000 adults, researchers have tried to determine the possible association between the stage of nephropathy and [...]
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In the AASK (African-American Study of Kidney Disease and Hypertension) trial, 1094 non-diabetic, black patients, with hypertension-related nephropathy, have been examined, randomizing them to a standard or intensive anti-hypertension treatment. In spite of the average pressure value obtained [...]
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We have recently seen a certain tendency to anticipate as much as possible the beginning of dialysis in patients with severe renal diseases, but is there an evidence justifying this tendency? In Australia and New Zealand a randomized trial has been performed, where 828 adults with chronic [...]
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The presence of albuminuria and the decrease of glomerular filtration (GFR) are indexes used to assess renal function, even if the values of normality levels are still debated. In order to clear up in a better way the problem and to verify also the influence of these parameters on mortality, a [...]
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Patients with chronic renal failure under dialysis treatment present high risks of mortality for cardiovascular causes. In order to verify whether also general mortality is increased, a cohort of 120,000 subjects recently enrolled in a dialysis program (average age 63; 61% males) in nine European [...]