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A population based nationwide study was carried out in Finland in patients with type 1diabetes mellitus, to examine the different mortality among 10,500 patients with diabetes from an early age (0-14 years) and 6,800 others who developed diabetes later in life (15-29 years). The mean follow-up was [...]
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It is known that the onset of diabetes mellitus type 2 is affected by lifestyle, but to what extent does each component of lifestyle affect this outbreak? A group of U.S. researchers analyzed data from a prospective cohort study involving over 200,000 participants, aged 50-71 years, not suffering [...]
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Glycosylated hemoglobin (HbA1c) is used because of its ability to measure mean plasma glucose (MPG) concentrations over the preceding 2-3 months; but since this is a mean, one problem arises: does an MPG over the preceding 3 months of 200 mg/dl express a limited variability in a very narrow range, [...]
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Recent studies have raised serious doubts on whether diabetes should be controlled intensively, since the incidence of cardiovascular events and mortality in the short period have not been favorably influenced by this kind of aggressive treatment. With this meta-analysis of 13 randomized [...]
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In patients with diabetes, the increase in microalbuminuria is associated with the onset of nephropathy and/or cardiovascular complications, and with high levels of microalbuminuria the recommended treatment involves the use of ACE-Inhibitors or of angiotensin-receptor blockers (ARBs). This study [...]
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The ACCORD study randomized 10,000 elderly patients with long-term type 2 diabetes to reach a level of HbA1c< 6% or a target between 7.0% and 7.9%, with interruption after 3.5 years of the intensive therapy, due to higher mortality in the intensive-therapy group compared to the standard-therapy [...]
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A number of studies has shown that treatments involving excessive doses of statins may be associated with patients developing insulin resistance, resulting in higher risk of developing type 2 diabetes. To examine this possibility, investigators carried out a meta-analysis of 5 randomized statin [...]
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Increased physical activity and dietary management is universally recommended in the initial treatment of type 2 diabetes. Yet, if these most-important treatments are started at diagnosis, what effects do they produce in the long run? To assess this issue, a recent British study randomized 593 [...]
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When diabetes mellitus is diagnosed in a patient showing no symptoms, what is the best therapeutic approach? In an effort to answer this question, a group of British, Danish and Dutch investigators randomized 343 general practices to treat, either with routine care or intensive treatment, 3,057 [...]
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If on the one hand type 2 diabetes is associated with higher bone density, paradoxically on the other hand it has increased fracture risk, which is difficult to assess using current methods (such as FRAX scoring or measuring bone mineral density [BMD] using DEXA scanning). In an effort to address [...]