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In the USA, about a third of women are obese, and this implies a whole series of negative results in case of pregnancy, even if it is not clear yet if and how obesity is a causal factor for possible fetal malformations. Some researchers have examined data relative to maternal BMI and the birth of [...]
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We know that physical activity decreases the risk of diabetes, unlike obesity and overweight, which increase it. Through a prospective analysis on data from the Physicians' Health Study, the association among levels of physical activity, BMI and incidence of diabetes has been evaluated in 20,000 [...]
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Cigarette smoke is a risk factor for the onset of type 2 diabetes, but smoke cessation often implies, beside the well-known benefits, an increase in body weight, too, which, in its turn, is a risk for diabetes. Some researchers have then examined the risk factors of diabetes onset in a cohort of [...]
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It is not easy to demonstrate the efficacy of glycemic control in the prevention of cardiovascular events, probably because this efficacy is not generalized but limited to some subgroups of diabetics. In order to determine whether HbA1c lowering from 7% to 6.5% has some effects on diabetics with [...]
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In previous trials, an association between the presence of sleeping apneas and glucose intolerance or insulin resistance has been found, but it has not been cleared up yet whether the presence of these apneas directly implies an increased risk of diabetes onset. In an observational cohort trial, [...]
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In 2002, the Diabetes Prevention Program (DPP) referred that interventions on lifestyle and the use of metformin (like the use of metformin alone) decrease the incidence of type 2 diabetes in the following 3 years in 3200 overweight adults affected by an impaired glucose tolerance, with a decrease [...]
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Drugs simulating the action of incretins stimulate insulin production, inhibit glucagone and suppress the sense of hunger in patients with type 2 diabetes. Within these drugs, in the USA, FDA has only approved the marketing of exenatide, while in Europe also liraglutide is available. In order to [...]
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Guidelines recommend the use of aspirin in the cardiovascular (CV) prophylaxis of patients affected by diabetes, but the evidence supporting this recommendation is not substantial. With a meta-analysis of 6 randomized case-control trials, involving more than 10,000 patients, some researchers have [...]
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The usual approach to newly diagnosed type 2 diabetes is to start pharmacological treatment with oral drugs and add insulin only in case patients are not capable to obtain the metabolic compensation in spite of the use of multiple therapies. With a trial concerning 58 diabetics (HbA1c was 10.8% at [...]
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It is a widespread opinion that the inhibition of the rennin-angiotensin system can prevent diabetic nephropathy and that, through similar mechanisms, it is also capable to prevent retinopathy. In order to verify these hypotheses, an international randomized trial has been performed, involving 285 [...]