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The detection of carotid stenosis is not uncommon in patients who have never experienced episodes of TIA, but there is no universal agreement on the need to perform screening in patients at risk (for example, those with coronary artery disease or carotid bruit), who later may undergo [...]
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Based on the results of several studies, it has been shown that statin use may somehow positively influence the course of Alzheimer disease. To investigate this, 406 patients with dementia were randomized to receive daily either 40 mg of simvastatin or placebo. At the beginning of the study, the [...]
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Dementia is obviously worsened by the onset of depression, but in these cases the use of an antidepressant has yet to be proved useful. A large, randomized study, which lasted 39 weeks, examined 326 patients with possible or probable Alzheimer's disease, followed by one of nine psychiatry services [...]
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Since there is evidence that neuroinflammation contributes to the pathogenesis of Parkinson’s disease, it has been suggested that the use of inflammation contrasting drugs may offer some sort of protection against this disease. A case-control study evaluated the relationship between NSAIDs and [...]
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It is traditional knowledge that patients should undergo a lumbar puncture to ascertain subarachnoid haemorrhage, independently of the results from CT. A recent prospective study investigated 3,132 neurological patients aged over 15 years, with third generation head CT scanning to evaluate [...]
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Is ischemic stroke due to the same causes in young adults as it is in older adults? In an attempt to answer this question, a retrospective analysis was carried out in France investigating the causes of acute ischemic stroke in 318 patients aged 16-54 years: nearly all patients underwent CT or MR [...]
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The American Academy of Neurology has released new guidelines on the treatment of painful diabetic neuropathy, based on the revision of the available literature, concluding that an only drug – pregabalin – can be defined as belonging to the “A” class, even if the studies on this product have shown [...]
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In the RE-LY study, on patients affected by atrial fibrillation and with a stroke risk, the administration of dabigatran (an oral inhibitor of thrombin) has reduced the risk of stroke and has presented a bleeding risk superimposable to the ones of warfarin. Researchers then has tried to investigate [...]
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One of the questions with no answer is the one relative to survival in patients with an advanced stage of dementia, and the answer to this question often influences the decisions of possible hospitalizations in palliative care structures. With a prospective study, the prevision of death among 606 [...]
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In patients suffering from migraine and tension-type headache, in general tricyclic agents are prescribed, even if antidepressants market has been occupied almost entirely by more recent drugs, like SSRIs. In order to compare their efficacy, a meta-analysis has been performed on 37 randomized [...]