Neurology 

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  • Metformin and Vitamin B12 Deficiency

    In some patients, according to observational trials, metformin can cause vitamin B12 deficiency, probably through an interference with its absorption. Since vitamin B12 deficiency can worsen neuropathies, the problem has been dealt with through a case-control trial, in Canada: out of 122 type 2 [...]


  • Tarenflurbil in Alzheimer’s Disease

    At the origin of Alzheimer’s disease, an accumulation of beta-amyloid in the nervous system is recognized, so drugs capable to interfere with this process theoretically have some possibilities to fight this disease. Tarenflurbil is a molecule influencing the production of amyloid through the [...]


  • Natural Evolution of Severe Dementia

    When a dement patient reaches the highest cognitive impairment, which is the natural course of his/her disease? In order to answer this question, some American researchers have performed an observational trial on 323 patients (averagely 85) accommodated in 22 shelters in the Boston area. All the [...]


  • Syncopes while Driving

    The onset of a syncope in a driver, beside risking his/her own life, is a danger also for possible people present at the event, so the evaluation of relapse risk becomes particularly important. In order to examine this problem, some researchers at Mayo Clinic have identified 3877 subjects [...]


  • Cortisones and Antiviral Agents in Bell Palsy

    Spontaneous recovery without any use of drugs is the rule in Bell palsy, but permanent results can occur in about 30% of cases, so an early treatment, capable to reduce the incidence of complications, becomes the main aim of the therapy. In order to obtain this, physicians use cortisones, antiviral [...]


  • Mediterranean Diet, Physical Exercise and Dementia

    It is well known that Mediterranean diet (much fruit, many vegetables, much olive oil, few saturated fats, few dairy products, a few meat) is associated with cardiovascular advantages, giving a protection also against cognitive decline. Through two new trials, this last association has been [...]


  • Biomarkers to Predict Alzheimer’s Disease

    Since Alzheimer’s dementia is one of the greatest problems in older age, it is clear that the early identification of symptoms and signs capable to predict the onset of the disease would be an important progress in prevention. From this point of view, some laboratory dosages referred to protein [...]


  • Duration of Anticoagulation Therapy After DVT

    There is no universal agreement yet on the optimal duration of anticoagulation therapy in a patient presenting a deep venous thrombosis (DVT). Some researchers in Italy have randomized 538 patients with DVT and a fixed or flexible anticoagulation therapy; all subjects had performed at least three [...]


  • Donepezil in Cognitive Disorders

    Many patients starting to present mild cognitive disorders (above all memory deficiencies) during time evolve towards a real Alzheimer dementia. In this trial sponsored by pharmaceutical industry researchers examined the efficacy of donezepil in 821 patients with a mild cognitive deficiency but not [...]


  • Secondhand Smoke and Cognitive Capability

    A meta-analysis in 2007 has shown that smoke is associated to a decrease in the cognitive capability (American Journal of Epidemiology 2007; 166:367), but the links of secondhand smoke with this capability remained unclear. Some researchers have then performed a cross-sectional trial on 4809 [...]


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