Internal medicine 

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  • Alcohol Abuse and Adherence to Therapies

    The repercussion of alcohol abuse on pharmacological therapies in general has not been deeply studied yet, so a retrospective trial has been performed using the data of the large Veterans Affairs database, taking clinical information of about 20,000 patients treated with statins, anti-hypertensive [...]


  • Quantitative Occult Blood Test

    Guaiac fecal occult blood test (FOBT) presents a low specificity and sensibility, so a quantitative immunochemical test specific for human hemoglobin was assessed, performing the examination on all subjects doomed to colonoscopy and followed by about 1.000 medical studies. Some of them were [...]


  • Venous Thromboemboslim Management: Guidelines

    According to a review based on clinical evidence, the American College of Physicians and the American Academy of Family Physicians published new guidelines for the management of venous thromboembolism. Recommendations contained in the document are:

    • in the treatment of deep venous [...]


    • Homocysteine and Venous Thromboembolism

      We know that high levels of homocysteine are associated with arterial thromboembolic risk. Some recent studies have however shown that the administration of some B-complex vitamins (decreasing homocysteine levels) is not able to prevent infarction or stroke onset. The doubt remains on secondary [...]


    • Which Objective in Hypercholesterolemia Treatment?

      The National Cholesterol Education Program recommends to progressively increase low-density lipoprotein therapy up to reducing LDL cholesterol to very low levels: for example less than 70 mg/dl in patients with a high cardiovascular risk. This recommendation was called into question by a lack of [...]


    • Asymptomatic Inguinal Hernia: What to Do?

      Two new trials published in the Annals of Surgery deal with the theme of the therapeutical behaviour with a patient affected by asymptomatic or a little symptomatic inguinal hernia.
      In Scotland 160 males (≥ 55 years of age) with asymptomatic hernias were randomized to surgery or to [...]


    • D-DIMER IN PULMONARY EMBOLISM

      According to the result of some studies, in situations in which the clinical probability of pulmonary embolism is low and the D-dimer negative, it is advisable not to administer anticoagulant therapies. In order to further verify this indication, two new studies have been realized. The first one, [...]


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