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In the USA, about a third of women are obese, and this implies a whole series of negative results in case of pregnancy, even if it is not clear yet if and how obesity is a causal factor for possible fetal malformations. Some researchers have examined data relative to maternal BMI and the birth of [...]
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In an international trial sponsored by pharmaceutical industry, 8556 women (averagely 67), responding to diagnostic criteria of osteoporosis, have been enrolled. For 5 years, they have been treated with placebo or with lasofoxifen, a selective modulator of estrogenic receptors, at the dosage of [...]
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In order to verify the usefulness of metformin in reducing body weight in teenagers, a multicentric, double-blinded trial has been performed, randomizing 77 obese, non-diabetics teenagers (between 13 and 18 years of age) to receive 2 g of metformin or placebo for 48 weeks, after a starting month of [...]
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There is a greater and greater evidence on the fact that the use of glitazones is associated with an increased risk of fractures and the pathogenetic mechanism is understandable: the receptors for glitazones are present in the bones and there are data indicating that rosiglitazone interferes with [...]
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According to recent trials, we know that there is an interference of protonic pump inhibitors (PPIs) in the action of clopidogrel, which is weakened. In order to evaluate the clinical importance of this interaction, 18,000 subjects ≥ 65 years of age, under therapy with clopidogrel after acute [...]
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In some patients, according to observational trials, metformin can cause vitamin B12 deficiency, probably through an interference with its absorption. Since vitamin B12 deficiency can worsen neuropathies, the problem has been dealt with through a case-control trial, in Canada: out of 122 type 2 [...]
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The efforts to obtain reliable and non-invasive coronary imaging techniques have led to CT and NMR, but, compared to traditional coronary angiography, do we obtain some advantages or do we “lose” some diagnoses? In order to clear up this problem, a meta-analysis of 89 trials relative to CT and 20 [...]
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Emergency contraception is based on levonorgestrel administration within 72 hours from a non-protected sexual intercourse. Ulipristal, a selective modulator of progestin receptors to be taken within 120 hours from the non-protected sexual intercourse, has been recently marketed with this purpose. [...]
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Beside the important role of vitamin D in calcium homeostasis, from some small prospective trials, it seems that this substance also intervenes in the prevention of colorectal cancer: in fact, an inverse association between plasmatic levels of 25(OH)-D and the presence of colorectal cancer has been [...]
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The results from some observational trials performed in England have suggested the hypothesis that venlafaxine, differently from other SSRIs, can more easily induce deaths for overdose because of its toxicity. Considering these data, the U.K. Medicines and Healthcare Products Regulatory Agency has [...]