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We know that congestive heart failure is a severe side effect of trastuzumab (Herceptin), used in 20-25% of women with HER2-positive breast cancer. Data coming from 173 patients with metastatic breast cancer treated with Herceptin from 1998 to 2003 (average treatment duration 21 months; average [...]
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From 1985 to 2002, neonatal mortality in the USA has decreased of 34%, while births of dead fetuses have decreased of only 18%. In the same period of time, the percentage of births from less young mothers (more than 35) has almost tripled. Data from the National Center for Health Statistics (more [...]
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Even if the use of atypical antipsychotic drugs in Alzheimer’s disease is spreading, evidences that the relation risks-benefits is in favour of these last ones lack. We know for certain that a notice by FDA in 2005 warned about the increase in mortality associated with the use of these drugs in [...]
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We know that ejaculation delay is one of the secondary effects of selective serotonin reuptake inhibitors (SSRI) use, so these products are sometimes used off label in premature ejaculation in order to exploit this characteristic. Long-acting SSRI require however long-term therapies which can cause [...]
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In patients affected by age-related macular degeneration, neovascularization is reliable for severe losses of sight, so a theoretically effective approach is made of therapies able to inhibit endothelial growth factor. In two studies sponsored by pharmaceutical industry were examined the effects of [...]
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In sinovial tissue there are many TLR (Toll-like receptors) receptors, inflammation mediators. Chaperonin 10, a mitochondrial protein inhibiting TLRs, could potentially have a therapeutical action in rheumatoid arthritis. In this multicentric study, sponsored by pharmaceutical industry, performed [...]
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Obesity in adult pregnant women is associated to a high maternal and neonatal risk, but too few studies have been performed in adolescence. In a retrospective, case-control study the outcomes of pregnancies were examined of girls (under 19 years of age) who had gave birth to a child after at least [...]
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According to Diabetes Prevention Program, a drastic intervention on the lifestyle of obese patients with impaired glucose tolerance has decreased the incidence of diabetes mellitus in the following three years compared to the normal management of these subjects. Afterwards, researchers have tried [...]
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In 2004 the INTERHEART study was performed, a case-control trial involving more than 12000 patients affected by myocardial infarction and more than 14000 healthy controls made equal for sex and age, enrolled in 52 nations of 6 continents. Conclusions were that most myocardial infarctions are due to [...]
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Some studies have supposed a relation between depression and sleep-related breath disorders (a wide term including both sleep apnoea and hypopnoea events). A study performed in Wisconsin has taken into consideration the variation of depression risk in relation with the severity of these disorders. [...]