-
Trying to help pharmacologically subjects wanting to lose weight, many drugs have been marketed, but quite all of them have been abandoned because of their side effects. A new attempt has been now performed in the USA randomizing 2,487 obese people (BMI 27-45 kg/m2, with two or more comorbities) to [...]
-
Two of the available thiazolidinodiones for the therapy of type 2 diabetes, pioglitazone and rosiglitazone, this second one has been gradually abandoned because of an increased risk of cardiovascular ischemic events, even if both cause an increased frequency of heart failures. With a meta-analysis [...]
-
In the first line, in the treatment of COPD and in its exacerbations, there are inhaled anticholinergics and long-action beta-agonists, but which of these two drug classes is more effective? In order to answer this question, an international, double-blinded, randomized study has been performed, [...]
-
The mechanism with which exenatide acts is well known: it increases insulin secretion, it decreases glucagone secretion and it slows gastric emptying down: its use is approved in association with any oral glucose-lowering drug but not with insulin. In this study, sponsored by pharmaceutical [...]
-
The outburst of systemic reactions associated with eosinophilia, a consequence of the assumption of a specific drug in the body which is known under the name of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) and it represents one of the worst inconvenient events linked to [...]
-
The risk of thromboembolic perioperative complications in patients undergoing hip prostheses is very high, so the prevention protocol implies the use of low-molecular-weight heparin or of vitamin K antagonists, like warfarin. Heparin requires however a subcutaneous injection, while warfarin needs [...]
-
In situations requiring a situation of reduced coagulability, like, for example, in deep venous thromboses (DVTs), a new series of drugs are gradually occupying important roles. Among these ones, the specific coagulation factor inhibitors, like rivaroxaban, which, through oral administration, [...]
-
Warfarin properties are well known: preventive efficacy in patients with AF and therapeutical efficacy in patients with pulmonary embolism and/or venous thrombosis, not considering its use in conditions of embolic risk or in patients with anticardiolipin antibodies syndrome. The use of warfarin, [...]
-
Dabigatran is an inhibitor of thrombin, authorized for its use in the prevention of stroke in patients with atrial fibrillation, showing the efficacy and the safety of warfarin but with some advantages compared to this one. The great problem of dabigatran is however represented by the cost-efficacy [...]
-
In the treatment of thrombocytopenic purpura, the used drugs are the ones capable to stimulate platelet production, even if these products, even obtaining an increase in the number of platelets, are not often capable to reach clinically significant results, antagonized as they are by the increased [...]