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Aliskiren – a direct inhibitor of rennin – was approved by FDA in 2007 for the treatment of hypertension, and now this trial, sponsored by pharmaceutical industry, was performed to verify whether a double block of the rennin-angiotensin-aldosterone system (reached with aliskiren plus a sartan) can [...]
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In patients with type 2 diabetes, home self-monitoring is generally advised as a means to obtain a satisfactory control of glycemic profile, exploiting the desire for health as a spur to improve glycemic situation. In a trial in 2007, however, there was no difference as to glycosylated hemoglobin [...]
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Many patients affected by type-2 diabetes mellitus need insulin in order to obtain glycemic compensation and recent guidelines suggest to start with a once-daily insulin, gradually increasing dosage up to an amount capable to control basal glycemia. Other trials prefer instead traditional [...]
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Infrared irradiation (defined as “Anodyne Therapy” by the producer) was proposed as effective in treating pain associated with diabetic neuropathy and its validity is promoted by the producer as “scientifically proven”. In order to verify its efficacy, a double-blinded randomized trial has been [...]
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Patients with type-2 diabetes and microalbuminuria can decrease their cardiovascular risk making an intensive treatment, of which however up to now nobody knew the effects on death risk. Then, a trial was performed in Denmark, where 160 type-2 diabetics with microalbuminuria have been intensively [...]
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In diabetics hospitalized in intensive care unit, physicians tend to use high dosages of insulin in order to keep glucose compensation, even if this practice derives from trials prevalently performed on subjects undergoing heart surgery. In this new trial performed in Germany 500 patients have been [...]
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A moderate alcohol intake is associated with a reduced incidence of type-2 diabetes, but we do not know yet which influence it has on the glucose system the introduction of little amounts of alcohol. In this trial performed in Israel, 109 people with type-2 diabetes have been examined, who, in the [...]
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The use of insulin in type-2 diabetes therapy often becomes a need and in order to better assess indications, in England a trial was performed (called 4-T, that is to say Treating To Target in Type 2 Diabetes) which compared three different options. 708 adults with type-2 diabetes with glycosylated [...]
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Even if it is not a novelty, the American College of Physicians has reviewed the Guidelines concerning the optimal control of patients affected by type-2 diabetes, and according to available evidences, it has recommended the following points: