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In the Treating to New Targets trial, 10000 patients with clear coronary disease and LDL levels lower than 130 mg/dl were randomized to receive low (10 mg) or high (80 mg) doses of atorvastatin. 5 years later, patients treated with 80 mg/die presented LDL levels significantly lower than the other [...]
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We know that congestive heart failure is a severe side effect of trastuzumab (Herceptin), used in 20-25% of women with HER2-positive breast cancer. Data coming from 173 patients with metastatic breast cancer treated with Herceptin from 1998 to 2003 (average treatment duration 21 months; average [...]
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In 2004 the INTERHEART study was performed, a case-control trial involving more than 12000 patients affected by myocardial infarction and more than 14000 healthy controls made equal for sex and age, enrolled in 52 nations of 6 continents. Conclusions were that most myocardial infarctions are due to [...]
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ACE-inhibitors reduce mortality and infarction in patients with heart failure or ventricular dysfunction. But are these positive effects present also in patients with coronary diseases without ventricular dysfunction? In three wide placebo-controlled randomized trials on patients affected by known [...]
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Cardiovascular (CV) diseases incidence is lower in women than in men, with a difference which is probably linked to the presence in blood of female hormones. In clinical trials of more than 40 years ago, estrogens administration to male subjects was associated to an increase in CV risk. Now, some [...]
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Theoretically, anticoagulants administered after a thromboembolic event should be interrupted when anticoagulation risks go beyond relapsing thromboembolism risks. Some studies suggested that relapse risk is higher in men than in women, while in other studies this difference was not checked. In [...]
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Physical activity is associated to a decrease in cardiovascular risk, but how much activity is necessary to obtain this effect in childhood? In order to answer to this question a cross-sectional study was performed (The European Youth Heart Study) involving 915 girls and 817 boys between 9 [...]
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It is known that obesity in adolescence is associated to an increase in cardiovascular risk, but it had not yet been investigated the possible association between obesity and premature death. So, the data of the Nurses' Health Study (a prospective trial started in 1989 and involving 102.400 women) [...]
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A wide American trial was used (27.480 women in good health of more than 45 years of age) to verify the possible relation between migraine and cardiovascular and cerebrovascular events. On 3610 participants affected by migraine (13%) in the years preceding the enrolment into the trial, 1434 (40%) [...]
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Since in preceding trials it was observed a low incidence of stroke in patients treated with statins, a randomized trial was then performed, sponsored by Pharmaceutical Industry, involving 4.731 patients, whose characteristics were: recent stroke or TIA, LDL-cholesterol between 100 and 190 mg/dl, [...]