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Endogen cannabinoids, interacting with type-1 cannabinoids (1CB) in adipose tissue, liver, skeleton muscles and other tissues, stimulate hunger and interfere with glucose and lipid metabolism. Rimonabant ( a selective blocker of 1CB receptors) decreases body weight and improves some cardiovascular [...]
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Diets based on a drastic decrease in carbohydrates associated to an increase in fats and proteins have acquired a great popularity, but it is not clear yet which are the long-term effects on cardiocirculatory system. In order to clarify this problem, the database of the Nurses' Health Study was [...]
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To lose weight is already difficult, but to maintain the loss is often a desperate undertaking, judging from the very great number of overweight or obese people regaining the starting weight after months of heavy diets. In this study performed at Brown University three different strategies to [...]
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The association between obesity (BMI ≥ 30) and mortality is well known, but some doubts still remain on overweight risks (BMI 25-29,9). In this American trial, more than 500.000 subjects (between 50 and 71 years of age) completed some questionnaires in the period between 1995 and 1996 involving the [...]
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Since sibutramine is efficacious in helping weight loss in adults, some researchers performed a randomized, multicentric trial, sponsored by Pharmaceutical Industry, comparing the drug with placebo in 498 adolescents (12 to 16 years of age) presenting a BMI higher than the 95th percentile. All [...]
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To lower the cardiovascular risk, people discuss whether it is better to follow as hypolipidic diet or the so-called Mediterranean-style diet. Some researchers in Spain have realized a three-month trial enrolling 772 asymptomatic adults (55 to 80 years of age) with diabetes mellitus or with three [...]